Sleeping pills and Effexor XR?

OTC sleep aids (including the one you are talking about) are basically just antihistamines. There should be no reaction. Just don't take more than the recommended dose. In the future if you continue to have sleep problems tell the doctor. He may want to give you trazadone or something with the effexor to help you sleep better. The med you want to take tonight is the same as the ingredient in Nyquil that makes you sleepy. You wouldn't hesitate to take nyquil if you had a cold would you?